Studies on the Carcinostatic Activity in Mice of 6-Azauracil Riboside (Azauridine), In Comparison with that of 6-Azauracil ‡
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منابع مشابه
The biochemical activity of 6-azauridine: interference with pyrimidine metabolism in transplantable mouse tumors.
Previous work has shown that the asymmetric triazine analogue of uridine, 6-azauracil riboside (azauridine), is a much more potent inhibitor of the growth of transplantable mouse tumors than is 6-azauracil (1,2). Presumably this difference in activity reflects the limited extent of the conversion of azauracil to azauridine in mammalian systems (3). On the other hand, formation of the 5’-phospha...
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http://www.revistadechimie.ro 964 It is established that analogues of natural nucleobases and nucleosides, containing nitrogen atoms have good antimetabolite [1, 2], antiviral, antibacterial [3, 4] antitumor and antimetastatic properties [5]. One of the first compounds obtained, exhibiting good antitumor and antimetabolite activity is 6-azauridine, an analogue of 6azauracil [2]. In recent years...
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methylhistidine), carnosine (ƒÀ-alanylhistidine) and CoA, and it is proposed to function in a limited number of synapses (1). It is well established that ƒÀ-alanine is a metabolite of uracil. Handschumacher (2) originally found that 6-azauridine 5'-phosphate is a competitive inhibitor of orotidine 5'-phosphate decarboxylase. Brody and Westheimer (3) purified orotidine 5'-phosphate decarboxylase...
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Cotton (Gossypium hirsutum L.) ovules grown in a defined nutrient medium undergo normal morphogenesis, including fiber production. In identical medium lacking boron, ovules callus and accumulate brown substances. Boron deficiency-like symptoms were induced by 6-azauracil and 6-azauridine in ovules growing in boron-sufficient media. Other nucleoside base analogs either reduced or had no effect o...
متن کاملSynthesis of Nitrogen Functional Derivatives of 5-substituted-6-azauracil as one of the Four Nucleobases in the Nucleic Acid of RNA
3-Arylhydrazono-2,4-dioxo-4-phenylbutanoateshave been prepared by the coupling of benzoylpyruvate with aryldiazonium chlorides.Reactions ofthe 3-arylhydrazono-2,4-dioxo-4-phenylbutanoateswith 1-aminoguanidine, semicarbazide, and thiosemicarbazidegave5-substituted 2-imino-6-azauracil (3a),6-azauracil (3b), and 2-thio-6-azauracil (3c), respectively. The analytical data of these compounds - IR, 1H...
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عنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 30 شماره
صفحات -
تاریخ انتشار 1957